The governing body of Mississippi County is entitled the County Commission and is composed of three County Commissioners.  The Presiding Commissioner is elected at-large for a four-year term and presides over the weekly regular meetings of the Commission.  The two Associate Commissioners are elected from each of their respective districts for four-year term, the district being divided by townships with each district being nearly equal in population as practicable and being of contiguous territory.

The County Clerk maintains permanent record of the proceedings of the County Commission (formerly County Court) and the records date back to 1845 the year Mississippi county was formed.  These records are maintained in the archives of the courthouse.